Siddhartha Banerjee

About

Postdoctoral Associate in the Department of Chemistry and Chemical Biology at Rutgers University, specializing in the structural analysis of amyloid aggregation in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. My current research focuses on uncovering structural motifs that drive amyloid aggregation. Previously, I explored the structural evolution of early-stage amyloid protein aggregates using advanced techniques like Atomic Force Microscopy (AFM) and nanoscale vibrational spectroscopy (AFM-IR). This work provided insights into the morphology and secondary structure of individual amyloid fibrils. I also investigated how neuronal membranes influence amyloid protein aggregation, leveraging high-resolution time-lapse AFM imaging to capture the aggregation process in real time. Passionate about applying cutting-edge analytical methods to unravel the molecular mechanisms underlying neurodegenerative diseases.

Work

Rutgers, The State University of New Jersey

US

Education

Rutgers, The State University of New Jersey

United States of America

The University of Alabama

United States of America
Postdoctoral Researcher

University of Nebraska Medical Center College of Pharmacy

United States of America
Postdoctoral Research Associate

Indian Association for the Cultivation of Science

India
Research Associate

Indian Association for the Cultivation of Science

India
PhD

Publications

Heterotypic Seeding Generates Mixed Amyloid Polymorphs

Small Science

journal-article

α-Synuclein emulsifies TDP-43 prion-like domain—RNA liquid droplets to promote heterotypic amyloid fibrils

Communications Biology

journal-article

Intermediate Antiparallel β Structure in Amyloid β Plaques Revealed by Infrared Spectroscopic Imaging

ACS Chemical Neuroscience

journal-article

Intermediate Antiparallel Fibrils in Aβ40 Dutch Mutant Aggregation: Insights from Nanoscale Infrared Spectroscopy

The Journal of Physical Chemistry B

journal-article

β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure

International Journal of Molecular Sciences

journal-article

β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure

International Journal of Molecular Sciences

journal-article

Nanoscale Infrared Spectroscopy Identifies Structural Heterogeneity in Individual Amyloid Fibrils and Prefibrillar Aggregates

The Journal of Physical Chemistry B

journal-article

Nanoscale Infrared Spectroscopy Identifies Parallel to Antiparallel β-Sheet Transformation of Aβ Fibrils

The Journal of Physical Chemistry Letters

journal-article

Structural heterogeneity of amyloid aggregates identified by spatially resolved nanoscale infrared spectroscopy

preprint

Structurally Distinct Polymorphs of Tau Aggregates Revealed by Nanoscale Infrared Spectroscopy

The Journal of Physical Chemistry Letters

journal-article

Structurally distinct polymorphs of Tau aggregates revealed by nanoscale infrared spectroscopy

other

Structurally Distinct Polymorphs of Tau Aggregates Revealed by Nanoscale Infrared Spectroscopy

The Journal of Physical Chemistry Letters

journal-article

Cholesterol in Membranes Facilitates Aggregation of Amyloid β Protein at Physiologically Relevant Concentrations

ACS Chemical Neuroscience

journal-article

Topographically smooth and stable supported lipid bilayer for high-resolution AFM studies

Methods

journal-article

Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers

International Journal of Molecular Sciences

journal-article

Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers

International Journal of Molecular Sciences

journal-article

Molecular Model for the Surface-Catalyzed Protein Self-Assembly.

The journal of physical chemistry. B

journal-article

Assembly of α-synuclein aggregates on phospholipid bilayers

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

journal-article

Interaction of Amyloidogenic Proteins with Membranes and Molecular Mechanism for the Development of Alzheimer’s disease

journal-article

Nanoscale Dynamics of Amyloid β-42 Oligomers As Revealed by High-Speed Atomic Force Microscopy

ACS Nano

journal-article

Nanoscale dynamics of centromere nucleosomes and the critical roles of CENP-A

Nucleic Acids Research

journal-article

A novel pathway for amyloids self-assembly in aggregates at nanomolar concentration mediated by the interaction with surfaces

Scientific Reports

journal-article

Nanoscale On-Silico Electron Transport via Ferritins

Langmuir

journal-article

Discriminating Intercalative Effects of Threading Intercalator Nogalamycin, from Classical Intercalator Daunomycin, Using Single Molecule Atomic Force Spectroscopy

PLOS ONE

journal-article

Molecularly resolved label-free sensing of single nucleobase mismatches by interfacial LNA probes

Nucleic Acids Research

journal-article

Interactions of Histone Acetyltransferase p300 with the Nuclear Proteins Histone and HMGB1, As Revealed by Single Molecule Atomic Force Spectroscopy

The Journal of Physical Chemistry B

journal-article

Nanoscale Mechano–Electronic Behavior of a Metalloprotein as a Variable of Metal Content

Langmuir

journal-article

Structural features of human histone acetyltransferase p300 and its complex with p53

FEBS Letters

journal-article

Near-Metallic Behavior of Warm Holoferritin Molecules on a Gold(111) Surface

Langmuir

journal-article